{"id":324,"date":"2024-04-23T15:44:16","date_gmt":"2024-04-23T18:44:16","guid":{"rendered":"https:\/\/dgbinst.wpengine.com\/beleza-transparente\/?page_id=324"},"modified":"2025-12-19T08:38:06","modified_gmt":"2025-12-19T11:38:06","slug":"science-and-innovation","status":"publish","type":"page","link":"https:\/\/www.grupoboticario.com.br\/beleza-transparente\/en\/science-and-innovation\/","title":{"rendered":"Science and Innovation"},"content":{"rendered":"\n
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BOTI BABY SKIN<\/a><\/h3>\n<\/div>\n\n\n\n
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EFFICACY AND SAFETY COMPUTATIONAL ANALYSIS<\/a><\/h3>\n<\/div>\n\n\n\n
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3D BIOPRINTING<\/a><\/h3>\n<\/div>\n\n\n\n
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3D SKIN<\/a><\/h3>\n<\/div>\n\n\n\n
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ORGANS ON <\/a>
A CHIP<\/a><\/h3>\n<\/div>\n\n\n\n
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PET SAFERY AND SCIENCE<\/a><\/h3>\n<\/div>\n\n\n\n
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ENVIRONMENTAL IMPACT OF FORMULAS<\/a><\/h3>\n<\/div>\n\n\n\n
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CONSUMER<\/a>
SCIENCES<\/a><\/h3>\n<\/div>\n\n\n\n
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DIGITAL<\/a>
NOSE<\/a><\/h3>\n<\/div>\n<\/div>\n\n\n
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boti baby skin <\/strong><\/em><\/p>\n\n<\/div><\/div><\/div>\n\n\n

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Botic\u00e1rio Group is pioneer in the country in the internal development of reconstituted tissue models for safety and efficacy testing of cosmetic products. Once we understand the particularities of adult and child skins, we dedicated our efforts to developing an in vitro reconstituted model that mimics the delicacy of child skin, resulting in Boti Baby Skin\u00ae.<\/p>\n\n\n\n

The development of Boti Baby Skin\u00ae <\/strong>was possible through the use of child cells undergoing a controlled laboratory process of cellular differentiation, similar to what happens in the human body, transforming these cells into tissues that mimic child skin\u2019s sensitivity. This model allows for more realistic and accurate testing of cosmetic products intended for children. 
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efficacy and safety computational analysis<\/em><\/strong><\/p>\n\n<\/div><\/div><\/div>\n\n\n

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\"mat\u00e9ria-prima
raw material (molecule in blue) interacting with a protein that degrades collagen (structure in green)<\/em>
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Currently, this aspect of analysis in Botic\u00e1rio Group is associated with the Alternative Methods research line, used in product development projects and, mainly, for prospecting attributes for proprietary raw materials under development. Bioinformatics is the science that uses information technology to understand and organize biological data.<\/p>\n\n\n\n

These analyses assist in a prior mapping of the action potential of a given molecule, enabling substantial savings in time and resources in the search for more assertive experimental validation.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Today, the bioinformatics analyses conducted in the laboratory comprise three fronts:<\/h2>\n\n\n
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1 – data collection<\/h2>\r\n <\/summary>\r\n
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Use of public databases or scientific literature to identify genes that have some type of interaction with the molecule of interest. This procedure facilitates the understanding and selection of assets based on scientific evidence about their influence on relevant biological processes.<\/p>\n\n<\/div>\r\n <\/div>\r\n <\/details>\r\n <\/div>\r\n<\/div>\r\n<\/div>\n\n\n

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2 – biological network<\/h2>\r\n <\/summary>\r\n
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It allows us to understand the interactions between genes\/proteins identified in the databases. Through these interactions, we can perform functional enrichment analyses to map which biological processes and pathways are altered, providing a perspective on how the active ingredients of a given product can promote the desired effect.<\/p>\n\n<\/div>\r\n <\/div>\r\n <\/details>\r\n <\/div>\r\n<\/div>\r\n<\/div>\n\n\n

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3 – virtual screening<\/h2>\r\n <\/summary>\r\n
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It is a computational technique that allows rapid screening of compounds with potential cosmetic activity for objectives associated with the desired attribute for a given product, saving time and resources. This analysis is performed with 3D simulations of the chemical interaction between the compound (ligand) and the biological target (protein).<\/p>\n\n<\/div>\r\n <\/div>\r\n <\/details>\r\n <\/div>\r\n<\/div>\r\n<\/div>\n<\/div>\r\n <\/div>\r\n<\/div><\/div>\n\n\n

Considering computational analyses of efficacy, bioinformatics techniques accelerate the process of screening and identifying compounds, reducing both costs and development time. In addition, this approach allows for more efficient production of cosmetics with innovative features. In this sense, knowing the molecular mechanisms by which a cosmetic active ingredient can act helps in the development of personalized products for specific needs with a more precise and efficient approach.<\/p>\n\n\n

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3D Bioprinting Innovation in Tissue Creation<\/strong><\/p>\n\n<\/div><\/div><\/div>\n\n\n

The Botic\u00e1rio Group is at the forefront of science and technology by incorporating 3D bioprinting into its research and development processes. With this innovative technology, we are increasingly advancing in the creation of three-dimensional tissues that mimic the structure and complexity of human skin. 3D bioprinting utilizes an advanced printing system where a computer coordinates the deposition of biomaterials, layer by layer, to form highly detailed tissues.<\/p>\n\n\n\n

The \u201cink<\/strong>\u201d used in bioprinting is composed of biological materials such as cells, proteins, and growth factors, ensuring a faithful recreation of skin structures. The key advantage of this technology is that the process allows for the inclusion of additional features, such as hair follicles, providing a more complete and functional modeling. With 3D bioprinting, we are not only advancing the science of tissues but also raising the standards of safety and efficacy of cosmetic products.<\/p>\n\n\n\n

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3D skin<\/strong><\/p>\n\n<\/div><\/div><\/div>\n\n\n

Botic\u00e1rio Group is committed to offering and implementing technologies that guarantee safety and effectiveness before launching products.<\/p>\n\n\n\n

We are the first company to develop a 3D skin in the country. This model was developed by researchers from Botic\u00e1rio Group Research and Development Center. It is an in vitro model that mimics human skin.<\/p>\n\n\n\n

In the laboratory, the skin is formed, cell by cell, layer by layer, just like human skin. First, the dermis<\/strong>, composed of fibroblasts, which are responsible for protein production<\/strong>, such as collagen, which give firmness and elasticity to the skin.<\/p>\n\n\n\n

The next layer is the epidermis<\/strong>, composed of cells called keratinocytes<\/strong>, responsible for the functions of body barrier and protection<\/strong>, and by melanocytes, responsible for skin pigmentation.<\/strong><\/strong><\/p>\n\n\n\n

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